Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 7th European Pediatrics and Pediatric Surgery Amsterdam, Netherlands.

Day 1 :

Conference Series Pediatric Surgery 2016 International Conference Keynote Speaker Robert E. Cilley photo
Biography:

Robert E. Cilley, MD completed General and Pediatric Surgery training at the University of Michigan. He is currently Professor of Surgery and Pediatrics and Ballantine Professor of Surgery at Penn State College of Medicine, Hershey, PA, USA.  He is the Chief, Division of Pediatric Surgery and Surgeon-in-Chief at Penn State Children’s Hospital, Milton S. Hershey Medical Center.  He was previously the medical director of the Pediatric Trauma Program.  He has published over 80 peer-reviewed articles and more than 30 book chapters. His areas of scholarly and professional interest include pediatric trauma, ECMO, lung development, surgical quality and safety.    

Abstract:

Selective non-operative management of hemodynamically stable pediatric trauma patients with blunt liver or spleen injury is the standard of care.

Traumatic bile leaks (TBL) may complicate liver injury.  TBL occurred in 294 patients with blunt hepatic trauma.  Symptoms of increasing abdominal pain, distension, nausea and vomiting 3 to 7 days after injury were suggestive. Hepatobiliary scanning was diagnostic. Combinations of peri-hepatic drain placement, ERCP with biliary stenting and/or sphincterotomy were performed with successful resolution of all TBL.  Median resolution was two weeks. No child required surgical repair of the leak.  Cholangitis developed in one child.  There were no long-term complications.  A multidisciplinary and minimally invasive approach employing peri-hepatic external drainage catheters and ERCP with sphincterotomy and stenting of the ampulla is a safe and effective management strategy for TBL in children.

   Pleural effusion (PlEf) as a complication of blunt splenic injury is not well described in children.  Of 274 non-operatively managed pediatric blunt splenic injures, 12 patients (4.4%) developed left-sided PlEf.   Seven of 12 patients required tube thoracostomy for worsening pleural effusion and respiratory insufficiency.  Median time to diagnosis of pleural effusion was 1.5 days.  Length of stay was 4 days for those without and 7.5 days for those with pleural effusions (p<0.001) and 6 and 8 days for those pleural effusions managed medically or with tube thoracostomy (p=0.006), respectively.  In multivariate analysis, high-grade splenic injury (IV-V) (OR 16.5, p=0.001) was associated with PlEf.   Some symptomatic patients may be successfully managed medically, while many require tube thoracostomy for progressive respiratory symptoms.

Keynote Forum

Stéphane Bolduc

CHU de Québec-Université Laval, Canada

Keynote: Overactive bladder in the pediatric population

Time : 09:30-10:10

Conference Series Pediatric Surgery 2016 International Conference Keynote Speaker Stéphane Bolduc photo
Biography:

Stéphane Bolduc has completed his Urology Residency at Université Laval and completed a fellowship in Pediatric Urology at The Hospital for Sick Children in Toronto. He is Chief of Pediatric Urology and the Director of Regenerative Medicine of CHU de Québec Research Center. He has published more than 70 papers in reputed journals and has been serving as Section Editor of Pediatric Urology of CUAJ

Abstract:

Overactive bladder (OAB) is a highly prevalent disorder in the pediatric population. This condition is especially troublesome for pediatric patients and their families when associated with incontinence since it negatively affects self-esteem and impairs children’s development. A stepwise approach is favored to treat this pathology, starting with behavioral therapy, followed by medical management, and eventually more invasive procedures. Antimuscarinic agents are the mainstay of medical treatment for OAB. Oxybutynin is the most commonly used antimuscarinic in the pediatric population. However, some patients have a suboptimal response to antimuscarinics and many experience bothersome side effects. Although there have been reports about the use of tolterodine, fesoterodine, trospium, propiverine and solifenacin in children, to date, only oxybutynin has been officially approved for pediatric in most countries. However, patients with severe OAB symptoms does not respond adequately to oxybutynin. After failure with a first pharmacologic molecule, most practitioners will try a more specific anticholinergic. We have already studied various options to treat children with non-neurogenic refractory OAB, namely trying a different antimuscarinic (tolterodine, fesoterodine, or solifenacin) as well as combining two different anticholinergics. Despite favorable results with these options, they remain unapproved for pediatric use and other therapeutic avenues are therefore worth investigating. Mirabegron, a new molecule with a distinct mechanism of action (β3-adrenoreceptor agonist), has recently been approved as monotherapy for idiopathic OAB in adults, but it has not been studied in the pediatric population. We recently concluded on two open-label studies to explore its efficacy and safety in children. It appears as a safe and effective alternative for children with idiopathic OAB refractory to antimuscarinics, in monotherapy or in association with antimuscarinics (add-on dual therapy). The different therapeutic alternatives reported could be included in a management algorithm for intractable OAB symptoms in children, but the need for prospective randomized controlled studies prior to official approbation is to be acknowledged

 

 

Keynote Forum

Jace Pillay

University of Johannesburg, South Africa

Keynote: The need for early childhood interventions for orphans and vulnerable children: An African perspective

Time : 11:10-11:50

Conference Series Pediatric Surgery 2016 International Conference Keynote Speaker Jace Pillay photo
Biography:

Jace Pillay completed his PhD in 1996 at the Rand Afrikaans University in South Africa. He is the South African Research Chair in Education and Care in Childhood. He has published more than 25 papers in reputed journals and has been serving as an Editorial Board Member of two highly reputable international journals. His research has been presented in numerous international conferences.

Abstract:

In the last decade, there has been a significant escalation in the number of orphans and vulnerable children in various parts of the world, more particularly, in Sub-Saharan Africa. The author strongly asserts that early childhood intereventions, particulary in the fields of health and education, are essential to address the plight of orphans and vulnerable children (OVC) in order for them to develop skills and human capital as future adults in order to break the cycle of poverty. Adopting the bio-ecological systems and social justice theoretical models, the author presents his current research findings on the educational, psychological and social experiences of OVC in South Africa. He argues that African governments should take on the responsibility of addressing the plight of OVC through early childhood interventions if they are serious about economic sustainability and prosperity. However, government cannot do this on its own so the joint collaboration of local communities and stakeholders will be necessary from an African perspective. Based on the findings of the study, the author challenges the rigorous application of the medical model and several western theories to children within the African context. In conclusion, several recommendations are made for the enhancement of the physical and mental health as well as the education and care of OVC during their early childhood years. Although the research discussed in this paper was conducted in South Africa, the author believes that the findings could easily depict what happens worldwide since OVC are prevalent even in the wealthiest of countries.

  • Pediatric Surgery
    Pediatric Emergency Medicine|
    Pediatric Immunology|
    Pediatric Surgery
    Pediatric Neurosurgery

Session Introduction

Xianming Carroll

Mercer University School of Medicine, USA

Title: A pair-matched case control study of family-environmental factors associated with ADHD in Chinese children

Time : 12:50-13:20

Biography:

Xianming Carroll has completed her MPH and PhD from Heinrich-Heine University Düsseldorf, Germany. She is Research Assistant Professor at Mercer University School of Medicine in the US. She has published several papers in peer-reviewed journals and has been serving as an Editorial Reviewer of journal PLoS One.

Abstract:

Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders, affecting an estimated 5 to 12% of school-aged children worldwide. Approximate 15 to 19 million Chinese children suffer from ADHD. The objective of this study was to investigate the association between family-environmental factors and ADHD in a sample of Chinese children. A pair-matched, case-control study was conducted with 161 ADHD children and 161non-ADHD children of matching age and sex, all from 5-18 years of age. The ADHD subjects and the normal controls were all evaluated via structured diagnostic interviews. We examined the association between family-environmental factors and ADHD using the conditional multiple logistic regression with backward stepwise selection to predict the associated factors of ADHD. Having experienced emotional abuse and being a single child were both significant factors associated with children diagnosed with ADHD. ADHD subjects were more likely to have suffered from emotional abuse (OR=11.09, 95% CI=2.15-57.29, P=0.004) and have been a single child in the family (OR=6.32, 95% CI=2.09-19.14, P=0.001) when compared to normal controls. The results were not modified by other confounding factors. Our findings provide evidence that family-environmental factors are associated with ADHD among children in China. These findings, if confirmed by future research, may help to decrease ADHD by increasing the awareness of the effects of childhood emotional abuse.

Rania Hosny Tomerak

Cairo University Children’s Hospital, Egypt

Title: Breastfeeding the preterm; a right must be done right

Time : 13:20-13:50

Speaker
Biography:

Rania Hosny Tomerak is a Professor of Pediatrics and Neonatology in Cairo University. She has completed her graduation in 1994, Master’s in Pediatrics in 1998 and Doctorate in Pediatrics in 2001. She is an international board certified Lactation Consultant since 2004. She is a board member of Lactation Education Accreditation and Approval Committee in USA, which provides approval and accreditation to all breastfeeding programs all over the world. She has published 21 scientific papers.

Abstract:

Breast milk is the white blood containing almost all the factors essential for the physical, physiological and psychological maturity of the preterm infant. Its function represents a continuum of the placental function. Preterm infants are inevitably deprived of the placenta in late pregnancy so the human factor should fight to provide the baby with this white blood; the breast milk. This needs a tight strategy to be mastered by the authorized personnel in the NICU. The policy should include the guidelines of milk expression, storage, transfer and providence to the baby. Promotion of the kangaroo mother care is an important adjuvant. Proper counselling of the mother is also of utmost importance together with the post discharge support of the mothers to continue breastfeeding.

Jinfen Liu

Shanghai Jiaotong University School of Medicine, China

Title: Decreased yes-associated protein 1 (YAP1) expression in pediatric hearts with ventricular septal defects

Time : 13:50-14:20

Speaker
Biography:

Jinfen Liu has completed his MD from Shanghai Jiaotong University School of Medicine. He is the Director of Shanghai Pediatric Congenital Heart Disease Institute, member of World Pediatric Heart Surgery Management Commitee, member of American Association for Thoracic Surgery, and Chairman of the Standing Committee of Chinese Pediatric Surgery. He has published more than 104 papers in reputed journals and has been serving as Associate Editor of World Journal for Pediatric & Congenital Heart Surgery.

Abstract:

Ventricular septal defects (VSDs) are the most common and simplest type of congenital heart diseases (CHDs). Animal studies have suggested that the downregulation of yes-associated protein 1 (YAP1) during embryonic development causes VSD associated CHDs. However, how YAP1 contributes to isolated VSD (iVSD) is unclear. 20 right atrial specimens were obtained from iVSD patients during routine congenital cardiac surgery and we assessed YAP1 expression in these specimens. For controls, six right atrial specimens were obtained from normal hearts of children without heart disease, three of whom died from cerebral palsy, and three who underwent heart transplants. YAP1 mRNA and protein levels and nuclear localization were significantly reduced in iVSD specimens compared to normal heart specimens. Concomitantly, mRNA levels of YAP1 downstream targets CTGF and AXL were also significantly decreased in iVSD specimens. Although Ki67-positive cardiomyocytes in iVSD specimens were comparable to normal heart specimens, Ki67-positive non- cardiomyocytes were significantly decreased. YAP1 expression was markedly decreased in hearts of iVSD children. Given the important role of YAP1 during heart development, downregulation of YAP1 expression may contribute to iVSD and affect the proliferation of non-cardiomyocytes.

Alana Jaye Coleman

University of Pittsburgh Medical Center, USA

Title: A Research Journey- Enhancing the Management of Congenital Diaphragmatic Hernia

Time : 14:20-14:50

Speaker
Biography:

Alana Jaye Coleman is a nurse who has completed her degree at the University of Pittsburgh. She has over fifteen years of experience in the Neonatal Intensive Care Unit (NICU) caring for infants born with Congenital Diaphragmatic Hernia. She was honored by The American Association of Colleges of Nursing (AACN) for her prestigious work done within this cohort. She is currently the Clinician of the NICU at the Children’s Hospital of the University of Pittsburgh Medical Center. She is a published first author in the Journal of Pediatric Surgery and continues to sponsor research studies and speak nationally.

Abstract:

A Research Journey- Enhancing the Management of Congenital Diaphragmatic Hernia (CDH) reflects at how one institution has evolved over time and increased survival in this distinct population. The journey was inspired by a nurse who wanted to make a difference after losing a patient to this terrible birth defect. A quality improvement study (QI) was sponsored to look at the current management of CDH patients to see if a change in practice needed to be made. At the completion of the study, a unanimous decision amongst pediatric surgery and neonatology was made to change current management to entail gentle ventilation, permissive hypercapnea, spontaneous respiration and delayed repair approach. A multidisciplinary team emerged to develop a protocol. After implementation of the protocol, the team continued to monitor, modify and explore its success. Six Institutional Review Board (IRB) studies have been sponsored, multiple poster and podium presentations have been given throughout the United States and Canada, and one article was published in the Journal of Pediatric Surgery. A Research Journey will provide specific details on the interventions, management and outcomes that have not only enhanced care but increased survival rate. The protocol starts prenatally, from the time of diagnosis and ends with discharge from the Neonatal Intensive Care Unit. Specific patients with low Magoon Indexes and inadequate total lung volumes, who are not candidates for ECMO, are discussed. Throughout the years we have learned you cannot save them all, but you can find redemption in the fight to try. 

Mehmet Emre Atabek

Necmettin Erbakan University School of Medicine, Turkey

Title: Prevalence of metabolic syndrome in children and adolescents

Time : 14:50-15:20

Speaker
Biography:

Prof Mehmet Emre Atabek has completed his PhD at the age of 24 years from Selcuk University,Turkey and postdoctoral studies from Selcuk University School of Medicine and Erciyes University School of Medicine . He is the director of Pediatric Endocrinology Department in Necmettin Erbakan University School of Medicine,Konya,Turkey. He has published more than 140 papers in international journals and  most of them indexed  in SCI/SCI-Expanded list.  He has existing intensive studies on obesity and he is a specialist in this field.

Abstract:

    Obesity is a risk factor for several metabolic complications. Impaired blood glucose regulation and metabolic syndrome are the most frequent of these complications. The aim was to investigate the impact of utilising different criteria on the prevalence of metabolic.

   143 obese children and adolescents aged between 8-17 recruited in the study. Metabolic syndrome was defined using International Diabetes Foundation (IDF) and World Health Organisation (WHO) definitions.

  In obese patient, 68 (47.6%) were male with a mean age of 12.22± 2.34, 75 (52.4%) were female with a mean age of 12.59±2.45. 112 (78.3%) of all patients were pubertal. Using WHO criteria, 80 (55.9 %) were newly diagnosed metabolic syndrome. Using IDF criteria, metabolic syndrome was present in 65 (45.5%) patient.

 The prevalence of metabolic syndrome, and diabetes in children and adolescent is increasing. In our study, we have noted a higher prevalance of metabolic syndrome with WHO criteria.

Hongchun

Guangdong Women and Children Hospital and Health Institute, China

Title: Management for intradiaphragmatic extralobar pulmonary sequestration—pediatric thoracoscope surgery postnatal and prognosis

Time : 15:40-16:10

Speaker
Biography:

Hongchun, Paediatric surgeon in Guangdong Women and Children Hospital and Health Institute. Master of Medicine from Guangzhou Medical College.He is the director of  Pediatric thoracic surgery.His team worked in the field about Fetal Medicine,especially for birth defect , and  pediatric surgery postnatal(Complete Video-Assisted Thoracoscopic  Surgery) especial for respiratory system, like CCAM, BPS. He has published more than 20 papers in reputed journals .

Abstract:

We retrospectively reviewed cases of bronchopulmonary sequestrations (BPS) diagnosed in our hospital from March 2011 to Sep 2015, in order to identify patients with IDEPS. Diagnosis of IDEPS was confirmed using prenatal Doppler ultrasound, postnatal intravascular enhanced computed tomography, and surgery. Summarized experience of surgical treatment by comparing the  cVATS 、VAMT and thoracotomy.

Erik Thaulow

University of Oslo,Norway

Title: Exercise in congenital heart disease

Time : 16:10-16:40

Speaker
Biography:

Dr.Erik Thaulow is a Professor at the University of Oslo, Department of Pediatrics and has been Head of Section for Congenital Heart Disease for 15 years. He has published several papers on the topic and has two times been part of the committee producing the ESC Guidelines on GUCH. He has been active in congenital heart disease (CHD) for 30 years .He has organized the GUCH-care at the University Hospital and served as Chairman of the Working Group for Adults with CHD in the ESC. 

Abstract:

There are essentially few restrictions given for exercise in congenital heart disease (CHD). Severe pulmonary hypertension, arrhythmias and risks of sudden drop in cardiac output are the most important factors. In addition some disease (Marfan) collision should be avoided in order to reduce the risk of aortic rupture. A survey on Norwegian children revealed that exercise was very infrequently related to mortality in CHD. It is more important to encourage these patients to be active and also participate in sports than give instructions to avoid sports. Exercise testing is important in individuals both to identify the few in whom exercise should be performed with great care, but most important, to demonstrate to the patient and the family (which should witness the exercise) that exercise activity is safe. Echocardiography done during exercise has been applied in order to study pulmonary hypertension during exercise. This is most often a research tool, but has also in some cases turned out to be of clinical importance. Physical training programs have been applied in CHD. Studies performed conclude that this is safe, there is some increase in oxygen uptake, and activity monitoring has revealed that the effect of such programs is mostly to give the participants greater participation in daily life physical activities. There are several guidelines on exercise in CHD. They should be known by physicians treating CHD patients, but the most important factor is to investigate the individual patients and encourage them to be physically active.

Speaker
Biography:

Dr. Peng Liu got his MD&PHD degree of Neurosurgery in 2011 from Southern Medical University, he also has been a postdoctoral visiting professor at Department of Biomedical Engineering of State University of New York at Stony Brook, USA. He is the associate professor of Department of Neurosurgery of Wuhan General Hospital of Guangzhou Military Command in Southern Medical University. His clinical skills includes cerebrovascular surgery(endovascular treatment of intracranial aneurysms, ateriovenous malformation and fistula, endovascular treatment of spinal vascular diseases, endovascular treatment of cerebral ischemic diseases, clipping of intracranial aneurysms, total resection of AVMs), craniocerebral  injury surgery and neuro-oncology surgery.

Abstract:

Background: Pediatric traumatic intracranial pseudoaneurysm (TIPA) is a relatively rare clinical entity resulting from blunt, penetrating or iatrogenic head trauma. The diagnosis, management and prognosis of patients with pediatric TIPA is not well-understood. Surgical craniotomy for TIPA is a high-risk operation. Advancements in minimally-invasive technology have allowed for endovascular reconstruction of TIPA. Case reports: We present our experience with use of endovascular covered stents for treatment of three pediatric cases with TIPA. The clinical and radiological characteristics are presented. No procedure-related complications or deaths occurred during follow-up. Conclusions: In this study, the use of Willis covered stent was associated with favorable prognoses in three patients with TIPA. No major complications were encountered during follow-up. The Willis covered stent appears to be a viable therapeutic modality in these patients. A definitive prognosis assessment will necessitate prospective clinical trials with longer duration of follow-up.

Alejandro Gonzalez

Escuela de Medicina, Pontificia Universidad Católica de Chile,Chile

Title: What preoperative information do the parents of children undergoing surgery want?

Time : 17:10-17:40

Speaker
Biography:

Alejandro González, MD, is anesthetist who performed a Fellow in Pediatric Anesthesia in Melbourne, Australia, in 1999. Since then, he has been working in pediatric and outpatient anesthesia. He was Director of an Ambulatory Surgery Center for five years (2001-2005), and he also was President of The Chilean Society of Anesthesiologists (2007-2009). He has published several papers about outpatient anesthesia and pediatric anesthesia.

Abstract:

Introduction: Parents feel fear and anxiety before elective surgery is performed on their child, and those feelings could obstruct their preparation for surgery. Preoperative information could relieve those feelings.

 Patients and method: A study was conducted on parents of children who underwent elective surgery. Demographic data of parents were recorded. Preoperative information received or would like to have received was assessed in terms of contents, methods, opportunity, place and informant. Descriptive statistics were used.

Biniam Ayele

Bahir Dar University, Ethiopia

Title: Whole colon mobility with cecocolic volvulus and literature review

Time : 17:40-18:10

Speaker
Biography:

Biniam Ayele graduated from University of Gondar as a Medical Doctor in 2012. Currently he is working as a Physician and Lecturer at Felegehiwot Referral Hospital and Bahir Dar University respectively. He is also a 3rd year Surgical Resident at Bahir Dar University.

Abstract:

Volvulus refers to torsion of a segment of the alimentary tract, which often leads to bowel obstruction. The most common sites of volvulus are the sigmoid colon and caecum. Volvulus of other portions of the alimentary tract, such as the stomach, gallbladder, small bowel, splenic flexure and transverse colon are rare. Patients with a caecal volvulus are young, with a mean age varying from 33 years in India to 53 years in Western countries. In contrast, sigmoid volvulus usually occurs in elderly subjects with chronic constipation or distal colon obstruction. The common presentations are colicky abdominal pain, abdominal distention, constipation/obstipation and depending on vascular status, the patient may be febrile and tachycardic. Here I present a case of cecocolic volvulus involving cecum, ascending colon, transverse colon and distal ilium in a 13 years old girl after she presented with colicky abdominal pain, distension, failure to pass feces and flatus for 3 days. She had also previous history of similar complaint but was self-limiting. She was febrile and tachycardic. Diagnosis was made by plain abdominal x-ray which showed air fluid level. She was prepared and operated and intraoperative finding was 360 degree clockwise rotated right colon and transverse colon along its mesentery which was ischemic and the whole large bowel was mobile and redundant with its own long mesentery. We extended right hemicolectomy and iliotransverse anastomosis. The patient was followed for 1 week in the ward and discharge improved. Now she is being followed in the surgical referral clinic. Details of the pathology, diagnosis and management will be discussed.